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Association between mild cognitive impairment and sleep quality in patients with chronic heart failure: a

Yanmei Gan1, Tingting Liao1, Yao Du1

  • 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Frontiers in Psychiatry
|November 26, 2025
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) is common in chronic heart failure (CHF) patients. Poor sleep quality is independently linked to MCI, suggesting sleep assessment is vital for cognitive health in CHF.

Area of Science:

  • Cardiology
  • Neurology
  • Sleep Medicine

Background:

  • Mild cognitive impairment (MCI) is a frequent comorbidity in chronic heart failure (CHF) patients.
  • MCI negatively impacts prognosis and quality of life in CHF.
  • The role of sleep quality in the relationship between MCI and CHF is under-researched.

Purpose of the Study:

  • To determine the prevalence of MCI and poor sleep quality in CHF patients.
  • To investigate the association between MCI and sleep quality in this population.

Main Methods:

  • A cross-sectional study involving 329 CHF patients.
  • Cognitive function assessed using the Beijing version of the Montreal Cognitive Assessment Scale (MoCA-BJ).
  • Sleep quality evaluated with the Pittsburgh Sleep Scale Index (PSQI).
  • Statistical analyses included point-biserial correlation and hierarchical regression.

Main Results:

  • High prevalence of MCI (58%) and poor sleep quality (70.52%) observed in CHF patients.
  • A significant positive correlation found between MCI and poor sleep quality (r = 0.322, P < 0.01).
  • Sleep quality remained an independent predictor of MCI after adjusting for confounders.

Conclusions:

  • Poor sleep quality is strongly and independently associated with MCI in patients with CHF.
  • Sleep assessment should be integrated into CHF management.
  • Interventions targeting sleep quality may help preserve cognitive function in CHF patients.
Keywords:
chronic heart failuremild cognitive impairmentrisk factorssleep disorderssleep quality

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