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Updated: Jan 10, 2026
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Endoscopic Resection of an Esophageal Gastrointestinal Stromal Tumor After Neoadjuvant Treatment: A New Paradigm for
Fabian Dario Rodriguez-Monaco1, Maximilian Herter1, Dolores Krauss2
1Department of Medicine/Gastroenterology, Gemeinschaftskrankenhaus Bonn, Bonn, Germany.
Abstract:
Esophageal gastrointestinal stromal tumors (eGISTs) are rare. Current guidelines recommend surgical R0 resection. Here, we report on a patient diagnosed with a larger (>30 mm) localized GIST in the midesophagus. After interdisciplinary discussion and discussion with the patient, we initiated a neoadjuvant therapy with imatinib 400 mg. The tumor was downsized and removed uneventfully by endoscopic tunneling resection. Histopathology showed a 19 × 18 × 17 mm ypT1-R1 eGIST. After shared decision-making, the patient continues therapy with imatinib and is in remission 1 year after resection. Downsizing by neoadjuvant treatment could increase the number of endoscopically resectable eGISTs.
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