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High Prevalence of Cold Intolerance in Rheumatoid Arthritis: A Case-Control Study.
Mohsen Soroush1, Rojin Farzaneh2, Elaheh Babapour2
1Department of Internal Medicine AJA University of Medical Sciences Tehran Iran.
Clinical Case Reports
|November 26, 2025
Summary
Cold intolerance is more common in rheumatoid arthritis patients. This condition develops after disease onset, often featuring pain and swelling, and negatively impacts quality of life.
Area of Science:
- Rheumatology
- Clinical immunology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Cold intolerance is a potential symptom in RA patients.
Purpose of the Study:
- To investigate the prevalence and characteristics of cold intolerance in rheumatoid arthritis patients.
Main Methods:
- Comparative analysis between RA patients and a control group.
- Assessment of symptom onset, duration, and features.
Main Results:
- Cold intolerance is significantly more prevalent in RA patients compared to controls.
- Cold intolerance typically manifests post-RA diagnosis and correlates with disease duration.
- Pain and swelling are the predominant symptoms associated with cold intolerance in RA.
Conclusions:
- Cold intolerance is a common comorbidity in rheumatoid arthritis.
- The presence of cold intolerance negatively affects the quality of life for RA patients.
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