PCK2, a SASP-Associated Gene, Serves as an Independent Prognostic Indicator in Diffuse Large B-Cell Lymphoma

Area of Science:

• Oncology
• Molecular Biology
• Bioinformatics

Background:

• Diffuse Large B-cell Lymphoma (DLBCL) exhibits significant heterogeneity.
• Senescence-associated secretory phenotype (SASP) plays dual roles in tumorigenesis.
• Limited research exists on SASP's impact on DLBCL.

Purpose of the Study:

• To identify a SASP-related indicator for DLBCL.
• To gain new insights into DLBCL pathology.
• To evaluate PCK2's potential as a prognostic marker.

Main Methods:

• Differential expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA) were used.
• Univariate Cox regression identified SASP-related genes as risk factors.
• Immunohistochemistry validated PCK2 expression in DLBCL tissues.

Main Results:

• PCK2 was identified as a key SASP-related gene in DLBCL.
• PCK2 demonstrated excellent prognostic performance (AUC=0.953, HR=1.89).
• PCK2 upregulation was confirmed in DLBCL tissues, associated with immunosuppression.

Conclusions:

• PCK2 serves as a potential indicator for DLBCL prognosis.
• PCK2 offers supplementary information for DLBCL monitoring.
• Further research into PCK2's role in DLBCL is warranted.