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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jan 10, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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Multifunctional ROS-responsive hydrogels alleviate subconjunctival inflammation.

Xing Wang1, Yuting Deng1, Boyuan An1

  • 1Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China. lijingguo@zzu.edu.cn.

Journal of Materials Chemistry. B
|November 26, 2025
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Summary
This summary is machine-generated.

A novel hydrogel (CPES) effectively scavenges reactive oxygen species (ROS) to suppress subconjunctival inflammation. This biomaterial offers a promising therapeutic strategy for preventing vision-threatening complications like fibrosis.

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Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Immunology

Background:

  • Persistent subconjunctival inflammation can lead to vision-threatening complications, including fibrosis.
  • Current pharmacological treatments for subconjunctival inflammation face limitations due to administration challenges and potential toxicity.
  • There is a critical need for advanced therapeutic approaches to effectively manage subconjunctival inflammation.

Purpose of the Study:

  • To develop and evaluate a novel multi-network hydrogel (CPES) for suppressing early subconjunctival inflammation.
  • To investigate the reactive oxygen species (ROS) scavenging properties of the CPES hydrogel.
  • To assess the therapeutic potential of CPES in a preclinical model of subconjunctival inflammation.

Main Methods:

  • A one-step mixing process was used to synthesize the CPES hydrogel, characterized by dynamic borate esters and thioether crosslinks.
  • The hydrogel's properties, including gelation stability, swelling, self-repair, ROS scavenging capacity, and cell compatibility, were evaluated.
  • The efficacy of CPES in controlling inflammation was tested in a rat model of subconjunctival injury.

Main Results:

  • CPES hydrogels demonstrated excellent gelation stability, appropriate swelling ratios, and robust self-adaptive/self-repair capabilities.
  • The hydrogel exhibited significant free radical scavenging capacity and good biocompatibility.
  • In a rat model, CPES effectively mitigated early-stage subconjunctival inflammation.

Conclusions:

  • CPES hydrogels possess desirable properties for therapeutic applications, including controllable biodegradability and potent ROS scavenging.
  • The developed hydrogel platform shows significant promise for controlling subconjunctival inflammation.
  • CPES represents a viable therapeutic strategy for preventing vision-threatening complications associated with subconjunctival inflammation.