Indole Hybrids With Therapeutic Potential Against Drug-Resistant Cancers: An Update (2021-2025)

Area of Science:

• Medicinal Chemistry
• Oncology
• Drug Discovery

Background:

• Drug-resistant cancer presents a significant challenge in clinical treatment, leading to adverse outcomes and increased healthcare costs.
• Indole derivatives are recognized as effective anticancer scaffolds due to their multitargeted therapeutic properties.
• Indole hybrids are particularly effective in combating drug resistance by employing multitargeted strategies.

Purpose of the Study:

• To review the therapeutic potential of indole hybrids against drug-resistant cancers.
• To cover literature published on indole hybrids since 2021.
• To discuss structure-activity relationships and mechanisms of action for future drug design.

Main Methods:

• Comprehensive literature search for indole hybrids and drug-resistant cancer research published since 2021.
• Analysis of structure-activity relationships (SAR) of identified indole hybrids.
• Evaluation of the mechanisms of action (MoA) of promising indole hybrid candidates.

Main Results:

• Indole hybrids demonstrate significant potential in overcoming various drug resistance mechanisms in cancer.
• Recent studies highlight novel indole hybrid structures with enhanced efficacy and targeted action.
• Key structure-activity relationships and mechanisms of action have been elucidated for several indole hybrids.

Conclusions:

• Indole hybrids represent a promising class of compounds for developing novel chemotherapeutics against resistant cancers.
• Further research into SAR and MoA will facilitate the rational design of next-generation indole hybrid anticancer agents.
• The findings support the continued investigation of indole hybrids to address the unmet need for effective cancer treatments.