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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...

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A Wearable Electro-Controlled Microneedle Device for Synergistic Rheumatoid Arthritis Therapy.

Shuijin Chen1,2, Fuqian Chen1, Xia Gong1

  • 1Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.

Small (Weinheim an Der Bergstrasse, Germany)
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a wearable electro-controlled microneedle device for rheumatoid arthritis (RA) therapy. The device offers on-demand drug release, significantly reducing inflammation and pain in RA models.

Keywords:
electro‐controlled releaseiontophoresismicroneedlerheumatoid arthritissynergistic therapy

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and pain.
  • Current systemic treatments for RA present challenges like side effects and poor patient adherence.
  • Existing microneedle (MN) technologies for localized drug delivery lack controlled release kinetics.

Purpose of the Study:

  • To develop a wearable electro-controlled microneedle device (EMND) for synergistic rheumatoid arthritis (RA) therapy.
  • To enable precise, on-demand, and localized drug delivery for improved RA management.
  • To overcome the limitations of conventional RA treatments and current microneedle technologies.

Main Methods:

  • The EMND integrates a microneedle array, conductive hydrogel, control circuit, and smartphone application.
  • Microneedles provide transdermal access to the affected joint site.
  • Electrically triggered iontophoresis via conductive hydrogel allows controlled, on-demand release of therapeutics.

Main Results:

  • EMND treatment in RA rat models significantly reduced inflammatory cytokine levels (11.38%-14.51% of baseline).
  • Pain thresholds in RA rat models were substantially increased (5.24-fold) following EMND treatment.
  • The device demonstrated precise spatiotemporal control over multiple therapeutic agents for synergistic effects.

Conclusions:

  • The wearable EMND provides a novel approach for synergistic RA treatment through controlled, localized drug delivery.
  • This technology enhances therapeutic autonomy and offers a promising alternative to conventional RA therapies.
  • The EMND platform has potential applications for managing other chronic inflammatory conditions.