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Updated: Jan 10, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

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Compound adsorption device in pathogen reduction technology removes multiple drugs from plasma components

Briana Greenwall1, Kathryn Reeder1, Waseem Qais Anani1,2

  • 1ARUP Laboratories, Salt Lake City, Utah, USA.

Transfusion
|November 26, 2025
PubMed

Insights

The INTERCEPT Blood System’s compound adsorption device effectively removed testosterone and common medications from plasma. This suggests a potential to reduce drug contamination and reconsider donor deferral policies.

Area of Science:

  • Transfusion Medicine
  • Pharmacology
  • Biotechnology

Background:

  • Blood donor eligibility criteria may exclude individuals based on medication use, potentially limiting the donor pool.
  • Current donor health questionnaires may not fully capture all prescribed medications, leading to potential risks in blood products.

Purpose of the Study:

  • To evaluate the efficacy of the compound adsorption device (CAD) in the INTERCEPT Blood System Pathogen Reduction Technology (PRT) for plasma.
  • To assess the removal of exogenous testosterone and specific FDA-listed drugs from plasma using CAD.

Main Methods:

  • Plasma from donors on testosterone replacement therapy or supplemented with apixaban and emtricitabine/tenofovir was treated with INTERCEPT PRT (amotosalen and CAD steps).
  • Quantitative assays measured drug concentrations before and after CAD treatment.
  • Statistical analysis included Wilcoxon signed-rank test and one-way ANOVA.

Main Results:

  • CAD reduced free and total testosterone by 75% and 74%, respectively.
  • Apixaban was removed below the limit of detection.
  • Emtricitabine and tenofovir concentrations decreased by 100% and 98%, respectively.

Conclusions:

  • The INTERCEPT PRT CAD effectively removes various drug classes from plasma.
  • This technology shows potential for mitigating drug contamination in transfusable plasma.
  • Findings may support revising medication-based donor deferrals to balance donor safety and product efficacy.
Abstract

Keywords:
CADPRTcompound adsorption devicedonor medicationspathogen reductionplasma donation

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