Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical characteristics and prognostic clinical factors of anti-gamma-aminobutyric acid-B receptor (GABAB-R) encephalitis in Türkiye: a multicenter study.

Neurological research·2025

Same author

Relationship between autonomic dysfunction and sexual dysfunctions in Parkinson's patients.

Frontiers in aging neuroscience·2025

Same author

The phenotyping dilemma in VRK1-related motor neuron disease: a Turkish family with young-onset amyotrophic lateral sclerosis caused by a novel mutation.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2025

Same author

Utility of Median Nerve Electrophysiological Parameters in Differentiating Immune-Mediated Demyelination From Compressive Median Neuropathy at the Wrist.

Muscle & nerve·2025

Same author

Cranial volume measurement with artificial intelligence and cognitive scales in patients with clinically isolated syndrome.

Frontiers in neurology·2024

Same author

The Influence of Cancer Type on Stroke Incidence: A Retrospective Study.

Clinical Medicine Insights. Oncology·2024

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Published on: September 8, 2023

Defining True Motor Conduction Block in Chronic Immune-Mediated Demyelinating Neuropathies: A Temporal

Metin Mercan¹, Vildan Yayla¹, Ayşe Kurt¹

¹Department of Neurology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

European Journal of Neurology

|November 26, 2025

Summary

This summary is machine-generated.

Abnormal temporal dispersion (TD) significantly impacts motor conduction block (CB) detection. New criteria accounting for TD are crucial for accurate diagnosis of motor CB in neuropathies.

Keywords:

abnormal temporal dispersion demyelinating neuropathies electrodiagnostic criteria immune‐mediated demyelination motor conduction block

More Related Videos

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Published on: September 8, 2023

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Area of Science:

Neurology
Electrophysiology
Nerve Conduction Studies

Background:

Abnormal temporal dispersion (TD) complicates motor conduction block (CB) detection in electrodiagnostics.
Current criteria lack explicit guidance on TD's role in motor CB identification.

Purpose of the Study:

Evaluate the influence of motor conduction velocity (MCV) slowing and TD on motor CB.
Develop TD-based electrodiagnostic criteria for precise motor CB identification.

Main Methods:

Retrospective analysis of electrophysiological data from 35 patients with chronic immune-mediated demyelinating neuropathies.
Linear regression models to assess relationships between MCV, TD, and proximal compound muscle action potential (p-CMAP) amplitude reduction.

Main Results:

p-CMAP amplitude reduction strongly correlated with TD and MCV changes in median, ulnar, and peroneal nerves.
TD explained 46.9-56.2% of p-CMAP amplitude reduction variability (median, ulnar, peroneal nerves).
Established nerve-specific TD thresholds for defining motor CB, with different cut-offs in the absence of abnormal TD.

Conclusions:

Significant p-CMAP amplitude decline doesn't always indicate true motor CB.
Accurate motor CB diagnosis necessitates nerve-specific criteria incorporating abnormal TD thresholds.