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Outcomes Following Surgery for Pancreatic Neuro-Endocrine Tumours: A Single-Centre Experience
Mina Fouad1, Sayed Ali Almahari2, Abed Moeti Zaitoun2,3
1Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.
Clinics and Practice
|November 26, 2025
Summary
Curative resection of pancreatic neuroendocrine tumours (PNETs) offers excellent survival. Adverse pathological features like higher grade and lymph node metastases increase recurrence risk and impact prognosis.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Pancreatic neuroendocrine tumours (PNETs) are rare neoplasms.
- Surgical resection is the primary curative treatment for localized PNETs.
- Understanding long-term outcomes and prognostic factors is crucial for patient management.
Purpose of the Study:
- To evaluate survival outcomes and recurrence patterns after curative-intent resection of PNETs.
- To identify clinicopathological factors influencing survival and recurrence.
Main Methods:
- Retrospective review of patients undergoing curative-intent PNET resection (August 2010 - March 2024).
- Data collection included demographics, histopathology, recurrence, and survival.
- Statistical analysis to identify prognostic factors.
Main Results:
- 86 patients included; median age 61.5 years.
- 5-year overall survival (OS) was 83.0%; median OS 143.3 months.
- Recurrence observed in 13.95%; factors like tumour grade, size, and lymph node metastases impacted disease-free survival (DFS).
Conclusions:
- Curative resection of PNETs is associated with excellent long-term survival.
- Adverse pathological features predict increased recurrence risk and poorer prognosis.
- Risk stratification based on pathological findings aids in personalized patient care.
