Patients Prefer Human Empathy, but Not Always Human Wording: A Single-Blind Within-Subject Trial of GPT-Generated vs....

Background/Objectives: Written discharge explanations are crucial for patient understanding and safety in emergency eye care, yet their tone and clarity vary. Large language models (LLMs, artificial intelligence systems trained to generate human-like text) can produce patient-friendly materials, but direct, blinded comparisons with clinician-written texts remain scarce. This study compared patient perceptions of a routine clinician-written discharge text and a GPT-5-generated explanation, where GPT-5 (OpenAI) is a state-of-the-art LLM, based on the same clinical facts in emergency ophthalmology. The primary objective was empathy; secondary outcomes included clarity, detail, usefulness, trust, satisfaction, and intention to follow advice. Methods: We conducted a prospective, single-blind, within-subject study in the Emergency Ophthalmology Unit of the University Hospital Centre Split, Croatia. Adults (n = 129) read two standardized texts (clinician-written vs. GPT-5-generated), presented in identical format and in randomized order under masking. Each participant rated both on Likert scales with 1-5 points. Paired comparisons used Wilcoxon signed-rank tests with effect sizes, and secondary outcomes were adjusted using the Benjamini-Hochberg false discovery rate. Results: Empathy ratings were lower for the GPT-5-generated text than for the clinician-written text (means 3.97 vs. 4.30; mean difference -0.33; 95% CI -0.44 to -0.22; p < 0.001). After correcting for multiple comparisons, no secondary outcome differed significantly between sources. Preferences were evenly split (47.8% preferred GPT-5 among those expressing a preference). Conclusions: In emergency ophthalmology, GPT-5-generated explanations approached clinician-written materials on most perceived attributes but were rated less empathic. A structured, human-in-the-loop workflow-in which LLM-generated drafts are reviewed and tailored by clinicians-appears prudent for safe, patient-centered deployment.