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Related Experiment Video

Updated: Jan 10, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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Serum miRNA Signatures in Cancer Cachexia Depend on Systemic Inflammation.

Terese Louise Schmidberger Karlsen1,2, Robin Mjelle2, Ola Magne Vagnildhaug1,2

  • 1Cancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.

Current Oncology (Toronto, Ont.)
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

Systemic inflammation significantly alters microRNA (miRNA) profiles in cancer cachexia patients, impacting survival. These distinct miRNA signatures suggest potential biomarkers for early detection of this complex syndrome.

Keywords:
MiRNAbiomarkerscachexiacancercolorectal cancerinflammation

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer cachexia is a debilitating syndrome characterized by involuntary weight and muscle loss.
  • Systemic inflammation is a key driver of cancer cachexia development.
  • Understanding the molecular mechanisms underlying cachexia is crucial for therapeutic development.

Purpose of the Study:

  • To investigate circulating microRNA (miRNA) profiles in patients with colorectal cancer.
  • To compare miRNA profiles between patients with and without cachexia and systemic inflammation.
  • To identify potential miRNA biomarkers for cancer cachexia.

Main Methods:

  • A multicenter, longitudinal observational study involving 168 patients with unresectable colorectal cancer.
  • Patients were categorized into four groups based on cachexia and C-reactive protein (CRP) levels.
  • Circulating miRNA profiles were analyzed using next-generation sequencing.

Main Results:

  • Patients with both cachexia and systemic inflammation showed significantly distinct miRNA profiles compared to those without.
  • Inflammatory cachexia was associated with poorer overall survival (HR 2.10, p < 0.001).
  • 82 differentially expressed miRNAs were identified in inflammatory cachexia, including the miR-320-family, miR-6087, miR-4488, miR-29a-3p, miR-194-5p, and miR-10a-5p, linked to muscle mass and metabolism.

Conclusions:

  • Systemic inflammation plays a pivotal role in cancer cachexia, suggesting its inclusion in diagnostic criteria.
  • Circulating miRNAs represent promising biomarkers for identifying cancer cachexia.
  • Distinct miRNA profiles in inflammatory cachexia highlight its biological uniqueness.