Relation Between Inflammatory Parameters and Insulin Resistance Indices in Cows During Early Lactation

Area of Science:

• Veterinary Medicine
• Animal Science
• Metabolic Disorders

Background:

• Early lactation in high-producing dairy cows presents challenges like negative energy balance, lipomobilization, and insulin resistance (IR).
• Low-grade systemic inflammation often accompanies these metabolic disturbances.

Purpose of the Study:

• To investigate inflammatory marker and IR index dynamics in early-lactation cows.
• To assess interrelationships between inflammation and IR.
• To evaluate the impact of NSAID (ketoprofen) administration on these parameters.

Main Methods:

• Thirty Holstein-Friesian cows were divided into control and ketoprofen treatment groups.
• Ketoprofen was administered intramuscularly during the first postpartum week.
• Blood samples analyzed for inflammatory markers (TNF-α, IL-1β, haptoglobin, fibrinogen), NEFA, glucose, insulin, and calculated IR indices (RQUICKI, HOMA-IR, QUICKI, Adipo-IR).

Main Results:

• Control cows showed increased inflammatory markers, NEFA, and adipose tissue IR (decreased RQUICKI, increased Adipo-IR).
• Positive correlations found between inflammatory markers, NEFA, and Adipo-IR.
• Negative correlations observed between inflammatory markers and glucose/insulin.

Conclusions:

• Ketoprofen treatment significantly reduced inflammation and NEFA, improving IR indices (RQUICKI, Adipo-IR).
• Inflammatory cytokines and adipose tissue IR indices are reliable indicators for monitoring inflammation-IR interactions.
• NSAID administration effectively modulates metabolic effects in early-lactation cows.