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Effects of Nicotine on SH-SY5Y Cells: An NMR-Based Metabolomic Study
Enza Napolitano1, Carmen Marino1, Manuela Grimaldi1
1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
Metabolites
|November 26, 2025
Summary
Nicotine, found in tobacco, impacts brain cell mitochondria and connections. This may explain nicotine
Area of Science:
- Neuroscience
- Metabolomics
- Cell Biology
Background:
- Nicotine is an alkaloid in tobacco with addictive properties.
- Tobacco use increases risks for cancer, metabolic, cardiovascular, and respiratory diseases.
- Nicotine may enhance cognitive functions in neurodegenerative diseases.
Purpose of the Study:
- To investigate the multifaceted effects of nicotine.
- To clarify the mechanisms underlying nicotine's actions using metabolomics.
Main Methods:
- NMR-based metabolomic analysis.
- Exposure of SH-SY5Y neuroblastoma cells to nicotine.
Main Results:
- Nicotine modulates mitochondrial function and membrane turnover.
- Nicotine influences mitochondrial bioenergetics.
- Nicotine impacts synaptic plasticity and neuronal connectivity.
Conclusions:
- Findings suggest nicotine affects mitochondrial and synaptic functions.
- These effects may underlie observed neuroprotective actions in neurodegenerative disease models.
