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Lipid Profile and Management of Dyslipidemias in Pregnancy

Constantine E Kosmas1, Loukianos S Rallidis1, Ioannis Hoursalas2

  • 12nd Department of Cardiology, National & Kapodistrian University of Athens, 12462 Athens, Greece.

Journal of Cardiovascular Development and Disease
|November 26, 2025
PubMed

Insights

Managing dyslipidemia during pregnancy is crucial for preventing atherosclerotic cardiovascular disease (ASCVD) and pregnancy complications. This review covers lipid metabolism changes and management strategies, including lifestyle and pharmacological options.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiology
  • Endocrinology

Background:

  • Dyslipidemia significantly elevates the risk of atherosclerotic cardiovascular disease (ASCVD).
  • Abnormal maternal lipid profiles during pregnancy are linked to complications like preeclampsia, gestational diabetes, and preterm delivery.
  • Elevated ASCVD risk affects both mother and child.

Purpose of the Study:

  • To review physiological changes in lipid metabolism during pregnancy.
  • To provide an overview of current dyslipidemia management strategies in pregnant women.
  • To focus on pharmacological therapy considerations for lipid disorders in pregnancy.

Main Methods:

  • Literature review of physiological changes in lipid metabolism during pregnancy.
  • Synthesis of current clinical guidelines and research on dyslipidemia management in pregnancy.
  • Analysis of safety and efficacy data for pharmacological interventions in pregnant populations.

Main Results:

  • Pregnancy involves significant, dynamic alterations in lipid metabolism.
  • Management requires individualized approaches combining lifestyle modifications and, when necessary, pharmacotherapy.
  • Specific pharmacological agents require careful consideration regarding safety and efficacy in pregnancy.

Conclusions:

  • Effective dyslipidemia management is essential for preventing ASCVD and optimizing pregnancy outcomes.
  • A multidisciplinary approach integrating lifestyle and targeted pharmacological therapy is key.
  • Further research is needed to refine pharmacological strategies for lipid management during pregnancy.

Keywords:
PCSK9bile acid sequestrantsdyslipidemiafibric acid derivativeslifestyle interventionslipid profilelipoprotein apheresisomega-3 fatty acidspregnancystatins

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