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Drug repurposing offers a cost-effective way to find new cancer treatments for animals. This review explores existing drugs like metformin and fenbendazole for veterinary oncology, highlighting their potential and challenges.

Keywords:
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Area of Science:

  • Veterinary Medicine
  • Oncology
  • Pharmacology

Background:

  • Drug repurposing is a cost-effective strategy for identifying new uses for existing drugs.
  • Veterinary oncology faces challenges in developing novel treatments due to high costs and time requirements.

Purpose of the Study:

  • To provide a comprehensive overview of repurposed drugs in veterinary oncology.
  • To evaluate the mechanisms of action, clinical benefits, and translational relevance of these agents.
  • To discuss combination strategies and challenges in clinical implementation.

Main Methods:

  • Review of existing literature on drug repurposing in veterinary oncology.
  • Analysis of preclinical research, naturally occurring tumor models, and clinical studies.
  • Critical evaluation of therapeutic potential, limitations, and combination strategies.

Main Results:

  • Identified various drug classes with repurposed potential, including NSAIDs, metabolic modulators, antiparasitics, immunomodulators, and cardiovascular agents.
  • Assessed evidence for clinical benefit and mechanisms of action for drugs like piroxicam, metformin, and fenbendazole.
  • Highlighted the potential of combination therapies to enhance treatment efficacy.

Conclusions:

  • Drug repurposing is a practical approach to expand therapeutic options in veterinary oncology.
  • Repurposed drugs can improve companion animal quality of life and advance comparative oncology.
  • Addressing challenges like funding and regulatory hurdles is crucial for clinical implementation.