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  1. Home
  2. Mental Health Among Caregivers Of Children With Nephrotic Syndrome: A Prospective Cohort Study.
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  2. Mental Health Among Caregivers Of Children With Nephrotic Syndrome: A Prospective Cohort Study.

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Mental health among caregivers of children with nephrotic syndrome: a prospective cohort study.

Tanay Joshi1,2, Cal H Robinson3,4, Nowrin Aman2,5

  • 1School of Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland.

Pediatric Nephrology (Berlin, Germany)
|November 26, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Caregivers of children with nephrotic syndrome face significant psychological distress, anxiety, and depression. Risk factors include child age, socioeconomic status, and treatment details, impacting caregiver well-being.

Keywords:
AnxietyCaregiverDepressionNephrotic syndromePediatricPsychological distress

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Area of Science:

  • Pediatric Nephrology
  • Psychological Health
  • Caregiver Support

Background:

  • Nephrotic syndrome in children presents unpredictability and a home monitoring burden for caregivers.
  • Psychological challenges like distress, anxiety, and depression are common but not well-understood in this population.

Purpose of the Study:

  • To determine the prevalence of psychological distress, anxiety, and depression among caregivers of children with nephrotic syndrome.
  • To identify risk factors associated with psychological distress in this caregiver group.

Main Methods:

  • Analysis of a prospective observational cohort (Insight into Nephrotic Syndrome) including 733 children and their caregivers.
  • Annual screening of caregivers for anxiety and depression using the Patient Health Questionnaire-4 over a median follow-up of 5.4 years.
  • Mixed-effects models were used to evaluate risk factors for psychological distress.
  • Main Results:

    • 36% of caregivers experienced mild or greater psychological distress; 14% moderate, and 5% severe.
    • 23% of caregivers screened positive for anxiety and 12% for depression.
    • Key risk factors identified: younger child age, parental unemployment, poor child quality-of-life, family dysfunction, language barriers, and active steroid treatment.

    Conclusions:

    • Over one-third of caregivers reported psychological distress, with significant rates of anxiety and depression.
    • Caregiver distress is linked to child demographics, treatment response, and socioeconomic factors.
    • Understanding these predictors is crucial for developing targeted support interventions for caregivers.