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Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation

Qun Xiao1,2, WeiCheng Huang1,2, Yuheng Zhuang3

  • 1Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

Aging Clinical and Experimental Research
|November 26, 2025
PubMed

Insights

The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index predicts stroke risk, particularly in those with normal glucose regulation or pre-diabetes. Monitoring the CHG index is crucial for preventing metabolic dysregulation-related strokes.

Area of Science:

  • Cardiovascular epidemiology
  • Metabolic syndrome research
  • Stroke prevention strategies

Background:

  • Stroke is a major public health concern influenced by metabolic factors.
  • The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index is a known stroke predictor.
  • The influence of glucose metabolism on CHG index and stroke risk requires further investigation.

Purpose of the Study:

  • To examine associations between CHG index (baseline, cumulative, longitudinal changes) and incident stroke risk.
  • To compare these associations across different glucose-metabolic states: normal glucose regulation (NGR), pre-diabetes (Pre-DM), and diabetes (DM).

Main Methods:

  • Analysis of 8,728 adults (aged ≥45) from the China Health and Retirement Longitudinal Study (CHARLS) (2011-2020).
  • Assessment of baseline, cumulative, and changes in CHG index.
  • Utilized Cox proportional hazards models and restricted cubic splines to analyze stroke incidence and dose-response relationships.

Main Results:

  • Stroke incidence rose with higher CHG index quartiles, except in individuals with DM.
  • The highest CHG quartile (Q4) was associated with a 1.7-fold increased stroke risk in NGR and Pre-DM groups.
  • No significant association between CHG index and stroke risk was observed in the DM group.

Conclusions:

  • Elevated CHG index is significantly linked to increased stroke risk, particularly in individuals with NGR and Pre-DM.
  • These findings underscore the importance of early monitoring and intervention for metabolic dysregulation.
  • Targeted strategies for managing CHG index may help mitigate stroke risk in specific metabolic states.
Abstract

Keywords:
Cholesterol, high-density lipoprotein, and glucose indexGlucose metabolism statusStroke risk

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