Klotho in aging and diseases: molecular features, expressions, and functional implications

Area of Science:

• Gerontology
• Molecular Biology
• Metabolism

Background:

• The protein Klotho is recognized for its significant anti-aging properties.
• Klotho deficiency accelerates aging and causes systemic organ deterioration, mimicking natural aging.
• Klotho offers protection against numerous age-associated pathologies and age-related tissue insults.

Purpose of the Study:

• To review the multifaceted roles of Klotho in the aging process.
• To emphasize Klotho's interactions with metabolic pathways vital for homeostatic equilibrium.
• To highlight Klotho's therapeutic potential for age-related conditions.

Main Methods:

• Literature review of studies on Klotho and aging.
• Analysis of Klotho's molecular mechanisms in aging.
• Examination of Klotho's role in metabolic regulation and senescence.

Main Results:

• Diminished Klotho levels in aged individuals correlate with accelerated aging and disease progression.
• Klotho protein demonstrates protective effects against various age-related tissue and organ damages.
• Klotho plays a crucial role in maintaining systemic homeostatic equilibrium through metabolic pathway interactions.

Conclusions:

• Klotho is a key regulator of aging, influencing lifespan and healthspan.
• Understanding Klotho's molecular mechanisms is crucial for developing anti-aging interventions.
• Klotho protein represents a promising therapeutic target for ameliorating age-related diseases and promoting longevity.