Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enzymes02:34

Enzymes

93.7K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
93.7K
Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

17.0K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
17.0K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.0K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.0K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.7K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ERGA-BGE reference genome of <i>Gambusia holbrooki</i>, a globally invasive freshwater fish.

Open research Europe·2026
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026
Same author

Apollo 3: Multi-Species Genome Curation.

bioRxiv : the preprint server for biology·2026
Same author

From "synthetic" to defined microbial communities for clearer terminology.

Nature communications·2026
Same author

A High-quality Reference Genome and Tissue Expression Atlas for the European Lobster (Homarus gammarus).

Genome biology and evolution·2026
Same author

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Nature communications·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor
07:21

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Published on: March 17, 2023

2.0K

Ensembl 2026.

Andrew D Yates1, Olanrewaju Austine-Orimoloye1, Andrey G Azov1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.

Nucleic Acids Research
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

The Ensembl project significantly expanded its genome database, releasing 1927 new genomes and improving access to genomic regulation data. They are transitioning to a new platform for sustainable scaling.

More Related Videos

Author Spotlight: Automated Lifespan Monitoring &#8211; Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.6K
Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
08:41

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Published on: June 13, 2025

1.1K

Related Experiment Videos

Last Updated: Jan 10, 2026

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor
07:21

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Published on: March 17, 2023

2.0K
Author Spotlight: Automated Lifespan Monitoring &#8211; Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.6K
Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
08:41

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Published on: June 13, 2025

1.1K

Area of Science:

  • Bioinformatics
  • Genomics
  • Comparative Genomics

Background:

  • Ensembl provides a comprehensive public resource for accessing and analyzing genomic data across diverse species.
  • The project continuously evolves to incorporate new genomes and enhance data accessibility and analytical tools.

Purpose of the Study:

  • To report on the recent expansion of the Ensembl genome database and introduce new features for exploring genomic regulation.
  • To outline the transition to a new Ensembl platform, ensuring sustainable scaling and continued resource development.

Main Methods:

  • Genome annotation and release processes were accelerated, leading to a near doubling of the release rate.
  • Development of new user interfaces for improved interrogation of genome regulation annotations.
  • Archiving of the Ensembl Rapid Release and migration to a new Ensembl platform.

Main Results:

  • Release of 1927 new genomes, bringing the total to 37,546, with expanded support for human and barley pangenomes.
  • Introduction of two novel interfaces for enhanced exploration of genome regulation data.
  • Successful archiving of Ensembl Rapid Release and acceleration of the move to the new Ensembl platform.

Conclusions:

  • The Ensembl project demonstrates substantial growth in genome data and improved analytical capabilities.
  • The transition to a new platform signifies a commitment to long-term sustainability and scalability of genomic resources.
  • Ensembl release 116 (Q1-2026) will mark the final release on the current platform, heralding a new era for the resource.