Ensembl 2026

Area of Science:

• Bioinformatics
• Genomics
• Comparative Genomics

Background:

• Ensembl provides a comprehensive public resource for accessing and analyzing genomic data across diverse species.
• The project continuously evolves to incorporate new genomes and enhance data accessibility and analytical tools.

Purpose of the Study:

• To report on the recent expansion of the Ensembl genome database and introduce new features for exploring genomic regulation.
• To outline the transition to a new Ensembl platform, ensuring sustainable scaling and continued resource development.

Main Methods:

• Genome annotation and release processes were accelerated, leading to a near doubling of the release rate.
• Development of new user interfaces for improved interrogation of genome regulation annotations.
• Archiving of the Ensembl Rapid Release and migration to a new Ensembl platform.

Main Results:

• Release of 1927 new genomes, bringing the total to 37,546, with expanded support for human and barley pangenomes.
• Introduction of two novel interfaces for enhanced exploration of genome regulation data.
• Successful archiving of Ensembl Rapid Release and acceleration of the move to the new Ensembl platform.

Conclusions:

• The Ensembl project demonstrates substantial growth in genome data and improved analytical capabilities.
• The transition to a new platform signifies a commitment to long-term sustainability and scalability of genomic resources.
• Ensembl release 116 (Q1-2026) will mark the final release on the current platform, heralding a new era for the resource.