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Ensembl 2026.

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The Ensembl project significantly expanded its genome database, releasing 1927 new genomes and improving access to genomic regulation data. They are transitioning to a new platform for sustainable scaling.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Comparative Genomics

Background:

  • Ensembl provides a comprehensive public resource for accessing and analyzing genomic data across diverse species.
  • The project continuously evolves to incorporate new genomes and enhance data accessibility and analytical tools.

Purpose of the Study:

  • To report on the recent expansion of the Ensembl genome database and introduce new features for exploring genomic regulation.
  • To outline the transition to a new Ensembl platform, ensuring sustainable scaling and continued resource development.

Main Methods:

  • Genome annotation and release processes were accelerated, leading to a near doubling of the release rate.
  • Development of new user interfaces for improved interrogation of genome regulation annotations.
  • Archiving of the Ensembl Rapid Release and migration to a new Ensembl platform.

Main Results:

  • Release of 1927 new genomes, bringing the total to 37,546, with expanded support for human and barley pangenomes.
  • Introduction of two novel interfaces for enhanced exploration of genome regulation data.
  • Successful archiving of Ensembl Rapid Release and acceleration of the move to the new Ensembl platform.

Conclusions:

  • The Ensembl project demonstrates substantial growth in genome data and improved analytical capabilities.
  • The transition to a new platform signifies a commitment to long-term sustainability and scalability of genomic resources.
  • Ensembl release 116 (Q1-2026) will mark the final release on the current platform, heralding a new era for the resource.