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EndoCompass Project: Research Roadmap for Diabetes, Obesity, and Metabolism
Chantal Mathieu1, Manuela Meireles2, Uberto Pagotto3,4
1Department of Endocrinology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
Hormone Research in Paediatrics
|November 26, 2025
Summary
Endocrinology research needs greater funding prioritization in Europe. The EndoCompass project identified key priorities in genetic factors, brain-periphery communication, and environmental influences to address hormone health challenges.
Area of Science:
- Endocrinology
- Hormone Health
- Metabolic Disorders
Background:
- Endocrine science is underrepresented in EU research funding, despite the significant impact of hormone disorders.
- A gap exists between the societal burden of endocrine diseases and their research prioritization.
- The EndoCompass project aims to define strategic research priorities in endocrine science.
Purpose of the Study:
- To identify and promote strategic research priorities in endocrine science.
- To address critical hormone-related health challenges.
- To align research funding with areas of highest potential impact.
Main Methods:
- Analysis of the EU CORDIS database (Horizon 2020).
- Expert consultations to identify key research priorities.
- Stakeholder engagement, including patient advocacy groups.
Main Results:
- Identified research priorities: genetic/epigenetic factors, brain-periphery communication, environmental influences.
- Key therapeutic areas: innovative treatments for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, behavioral interventions.
- Type 1 diabetes priorities: early detection, advanced insulin delivery, disease-modifying therapies.
Conclusions:
- Provides an evidence-based roadmap for strategic research investment in endocrinology.
- Identifies crucial areas for investigating diabetes and obesity pathophysiology, prevention, and treatment.
- Aims to reduce the burden of metabolic disorders and improve endocrine health outcomes.
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