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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Articles linked to this work by shared authors, journal, and citation graph.

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Endocrinopathies and growth in a UK cohort of children with transfusion dependent thalassaemia.

British journal of haematology·2026
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Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology.

Katharina Jähn-Rickert1,2, Karin Zibar Tomšić3, Athanasios D Anastasilakis4

  • 1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, k.jaehn@uke.de.

Hormone Research in Paediatrics
|November 26, 2025
PubMed
Summary

Endocrinology research needs greater EU funding to address hormone health challenges. The EndoCompass project identified key priorities in metabolic bone diseases, aiming to reduce patient burden and align research with societal impact.

Keywords:
BoneBone mass acquisitionBone mineralizationBone qualityCalciumCellular senescenceDiagnostic technologiesHypoparathyroidismHypophosphataemiaInactivating PTH/PTHrP signalling disordersOsteocytesOsteoporosisParathyroid hormonePhosphatePrimary hyperparathyroidismSkeletal dysplasiaTargeted treatmentsVitamin D

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Area of Science:

  • Endocrinology
  • Metabolic Bone Diseases
  • Hormone Health

Background:

  • Endocrine science is underrepresented in EU research programs.
  • A gap exists between endocrine disorder impact and research prioritization.
  • The EndoCompass project aims to define strategic research priorities in endocrinology.

Purpose of the Study:

  • Identify and promote strategic research priorities in endocrine science.
  • Address critical hormone-related health challenges.
  • Align research funding with areas of highest potential impact.

Main Methods:

  • Analyzed the EU CORDIS database (Horizon 2020).
  • Conducted expert consultations in bone and calcium endocrinology.
  • Engaged broader stakeholders, including patient groups.

Main Results:

  • Priorities include hyperparathyroidism, hypoparathyroidism, and rare calcium-phosphate disorders.
  • Key areas: bone as an endocrine organ, osteoporosis, skeletal dysplasias.
  • Focus on senescence, sex-specific differences, and diagnostic tools for bone quality.

Conclusions:

  • Provides a roadmap for strategic research investment in metabolic bone diseases.
  • Identifies crucial areas for pathophysiology, prevention, and treatment.
  • Aims to reduce the burden of endocrine disorders on individuals and society.