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EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology
Katharina Jähn-Rickert1,2, Karin Zibar Tomšić3, Athanasios D Anastasilakis4
1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, k.jaehn@uke.de.
Hormone Research in Paediatrics
|November 26, 2025
Summary
Endocrinology research needs greater EU funding to address hormone health challenges. The EndoCompass project identified key priorities in metabolic bone diseases, aiming to reduce patient burden and align research with societal impact.
Area of Science:
- Endocrinology
- Metabolic Bone Diseases
- Hormone Health
Background:
- Endocrine science is underrepresented in EU research programs.
- A gap exists between endocrine disorder impact and research prioritization.
- The EndoCompass project aims to define strategic research priorities in endocrinology.
Purpose of the Study:
- Identify and promote strategic research priorities in endocrine science.
- Address critical hormone-related health challenges.
- Align research funding with areas of highest potential impact.
Main Methods:
- Analyzed the EU CORDIS database (Horizon 2020).
- Conducted expert consultations in bone and calcium endocrinology.
- Engaged broader stakeholders, including patient groups.
Main Results:
- Priorities include hyperparathyroidism, hypoparathyroidism, and rare calcium-phosphate disorders.
- Key areas: bone as an endocrine organ, osteoporosis, skeletal dysplasias.
- Focus on senescence, sex-specific differences, and diagnostic tools for bone quality.
Conclusions:
- Provides a roadmap for strategic research investment in metabolic bone diseases.
- Identifies crucial areas for pathophysiology, prevention, and treatment.
- Aims to reduce the burden of endocrine disorders on individuals and society.
Keywords:
BoneBone mass acquisitionBone mineralizationBone qualityCalciumCellular senescenceDiagnostic technologiesHypoparathyroidismHypophosphataemiaInactivating PTH/PTHrP signalling disordersOsteocytesOsteoporosisParathyroid hormonePhosphatePrimary hyperparathyroidismSkeletal dysplasiaTargeted treatmentsVitamin DMore Related Videos
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