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Updated: Jan 10, 2026
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
Neutral red functionalized upconversion nanoparticles as ratiometric luminescence nanoprobes for high sensitively and
Xuan Xiao1, Xuemei Dong1, Yuchen Du2
1School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China; Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Anhui 234000, China.
Abstract:
The residues of megestrol acetate (MA) in food and the environment had posed potential risks to ecological safety and human health. Here, we had developed a ratiometric luminescence nanoprobe using neutral red (NR)-functionalized upconversion nanoparticles (UCNPs) and luminescence resonance energy transfer (LRET) for highly sensitive MA detection. Through the host-guest reaction between NR and γ-Cyclodextrin (γ-CD), NR had been assembled into the γ-CD cavities on the surface of UCNPs@γ-CD, quenching the green upconversion emission at 540 nm while activating the characteristic luminescence of NR at 600 nm, which had enabled dual-signal ratiometric detection. The probe had achieved a detection limit of 0.81 μM (S/N = 3) and had performed well in milk, fetal bovine serum, and bovine liver samples. This study had provided a highly specific and environmentally friendly analytical method for the precisely screening of hormone residues in animal-derived foods.
