Beyond hyponatremia: The crucial role of hypernatremia and hypokalemia in pediatric intussusception surgical outcomes
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric intussusception patients with electrolyte imbalances, especially hypernatremia and hypokalemia, face higher surgical complication risks. Early serum sodium and potassium assessment can guide treatment decisions.
Area Of Science
- Pediatric Surgery
- Pediatric Gastroenterology
- Clinical Chemistry
Background
- Electrolyte imbalances, including hyponatremia, are linked to disease severity in pediatric gastrointestinal conditions.
- The prognostic value of serum potassium and comprehensive electrolyte assessment in pediatric intussusception outcomes is not well-established.
Purpose Of The Study
- To determine the association between presenting serum sodium and potassium levels (dysnatremia and dyskalemia) and major surgical complications in children with intussusception.
Main Methods
- Retrospective, multicenter cohort study of 11,111 pediatric patients with intussusception.
- Analysis of baseline serum sodium and potassium levels within one day of diagnosis.
- Evaluation of surgical outcomes including open reduction, bowel perforation/resection, and peritonitis/sepsis using Cox proportional hazards models.
Main Results
- Electrolyte disturbances were common: hyponatremia (9.3%), hypernatremia (1.8%), hypokalemia (4.7%), hyperkalemia (2.8%).
- Higher surgical complication rates were observed in patients with electrolyte abnormalities.
- Hypernatremia showed the strongest association with severe complications (C3: aHR 7.89; C2: aHR 6.65). Hypokalemia was also significantly associated with C3 (aHR 4.20) and C2 (aHR 2.69).
Conclusions
- Electrolyte abnormalities, particularly hypernatremia and hypokalemia, are significant early indicators of surgical risk in pediatric intussusception.
- Routine assessment of serum electrolytes at presentation can aid in timely triage and surgical decision-making.
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