Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

8.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.8K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Clinical Trials01:16

Clinical Trials

10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

136
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
136
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

212
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
212
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

860
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
860

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the validity of Diet ID™ for measuring Healthy Eating Index.

Nutrition and health·2026
Same author

A cognitive dissonance-based intervention to reduce ultra-processed food intake: Protocol for a pilot randomized controlled trial.

Contemporary clinical trials·2026
Same author

Do routinized eating behaviors support weight loss? An examination of food logs from behavioral weight loss participants.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same author

Comparing Barriers and Facilitators to Interacting with Nature among Individuals with Different Dietary Behaviors: A Mixed Methods Study.

The Journal of nutrition·2026
Same author

The connections among interactions with nature, diet quality, and sustainable eating: Insights from a mixed methods study.

Social science & medicine (1982)·2026
Same author

Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety.

PLoS medicine·2026
Same journal

The sequential cohort randomized clinical trial: A study design for community-engaged clinical research in a rural American Indian community.

Contemporary clinical trials·2026
Same journal

Rationale, design, and statistical analysis plan for a randomized, double-blind, placebo-controlled trial of Limosilactobacillus reuteri to support mother-infant bonding and maternal socioemotional functioning in postpartum women at increased risk for postpartum depression.

Contemporary clinical trials·2026
Same journal

Effectiveness of clinical trial recruitment strategies in a safety-net hospital.

Contemporary clinical trials·2026
Same journal

Are older adult research participants representative of the general population? Results from 19 clinical studies at one academic research center.

Contemporary clinical trials·2026
Same journal

Multi-site feasibility of a web-based and telephone navigation intervention to connect lung cancer caregivers in community oncology settings with resources: Protocol for the WF-2301CD Caregiver Oncology Needs Evaluation Tool (CONNECT) trial.

Contemporary clinical trials·2026
Same journal

Rationale and design of a CArdiac rehabilitation program on the prevention of CardioTOXicity in breast Cancer patients undergoing treatment with anthracyclines and/or trastuzumab (CARPTOX-BC) trial: A randomized, active control group, open-label trial.

Contemporary clinical trials·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.2K

Protocol for a pilot RCT investigating a weight loss navigation program for adults.

Hannah I Silverstein1, Evan Forman1, Adam Gilden2

  • 1Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Stratton Hall, Philadelphia, PA 19104, USA.

Contemporary Clinical Trials
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

Patient navigators may improve weight loss intervention engagement for adults with overweight or obesity. This pilot study tested navigators

Keywords:
BehavioralInterventionNavigatorObesityWeight-loss

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.1K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.6K

Related Experiment Videos

Last Updated: Jan 10, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.2K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.1K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.6K

Area of Science:

  • Obesity and Weight Management
  • Health Services Research
  • Behavioral Medicine

Background:

  • Low utilization and suboptimal long-term engagement characterize evidence-based weight loss interventions for adults with overweight or obesity.
  • Self-guided weight loss attempts often lack efficacy.
  • Patient navigators show promise in improving healthcare engagement but their role in weight management is understudied.

Purpose of the Study:

  • To pilot a randomized clinical trial evaluating patient navigators for increasing uptake and persistence with evidence-based weight loss interventions.
  • To assess the feasibility, acceptability, and preliminary efficacy of a weight loss navigator program.
  • To inform future weight management program development and clinical practice.

Main Methods:

  • A 12-month pilot randomized clinical trial involving 68 adults with a BMI >27 kg/m2 interested in weight loss.
  • Participants were randomized to either usual care or a navigator condition.
  • The navigator condition included individual sessions and personalized emails to support intervention engagement. Remote assessments occurred at 0, 6, and 12 months.

Main Results:

  • The primary outcome is weight change after 12 months, with preliminary efficacy data pending.
  • The study will provide data on the feasibility and acceptability of the navigator intervention.
  • Analysis will focus on differences in weight change between the navigator and usual care groups.

Conclusions:

  • Patient navigators represent a potential strategy to enhance engagement with evidence-based weight loss interventions.
  • This pilot study's findings will guide the refinement of navigator programs for adults seeking weight loss.
  • Successful implementation could improve public health by increasing adherence to effective weight management strategies.