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Updated: Jan 10, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
Published on: August 13, 2010
Flicking the switch for B-cell development
Ashley P Ng1,2,3,4, Stephen L Nutt5,2
1Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
None:
The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to allow the ordered expression of genes essential for B-cell development. In this issue of Genes & Development, Tingvall-Gustafsson and colleagues (doi:10.1101/gad.353002.125) have investigated the interplay of these transcriptional regulators with the chromatin state of developing lymphocytes at single-cell resolution. They pinpoint a rare population of progenitors where this epigenetic reprogramming occurs to simultaneously repress the expression of lineage-inappropriate genes and activate the B-cell program.
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