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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.

Yang Li1, Fulong Man2, Jianwei Cheng2

  • 1Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, Department of Pharmacy, School of Medicine, Tongji University, Shanghai, 200065, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

Engineered fever therapy (EFT) uses controlled heat to activate the immune system for disease treatment. This approach enhances precision and safety, offering new possibilities for cancer therapy.

Keywords:
engineered fever therapyfeversnanomaterialsthermal immunotherapy

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Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Fever is a natural immune response with therapeutic potential.
  • Engineered fever therapy (EFT) aims to harness fever for disease management, especially in cancer.
  • Current EFT methods face challenges in precision and safety due to unpredictable temperature fluctuations and immune responses.

Purpose of the Study:

  • To review the molecular and physiological basis of fever.
  • To evaluate fever's therapeutic applications.
  • To present advancements in thermal immunotherapy and controllable EFT for precision oncology.

Main Methods:

  • Integration of precision thermal modulation with nanotechnology for targeted fever induction.
  • Development of controllable EFT based on three core principles: precise induction, quantitative immune reprogramming, and optimized safety.
  • Comprehensive review of existing literature on fever, EFT, and thermal immunotherapy.

Main Results:

  • Thermal immunotherapy enables targeted induction of fever-range temperatures (38.5-40 °C) in tumor sites.
  • Controllable EFT offers precise fever induction with input/process control, quantitative immune pathway reprogramming, and enhanced safety.
  • Recent progress in thermal immunotherapy and EFT has been made.

Conclusions:

  • Controllable EFT represents a new paradigm in disease management, particularly in precision oncology.
  • This approach holds significant therapeutic potential by leveraging physiological fever mechanisms with bioengineering.
  • Further research and clinical translation are needed to overcome challenges and realize the full opportunities of controllable EFT.