The association of serum uric acid level and the uric acid to creatinine ratio with non alcoholic fatty liver disease in children with obesity
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated serum uric acid (sUA) to creatinine (Cr) ratio is linked to increased Non-alcoholic fatty liver disease (NAFLD) risk in obese children. However, sUA levels alone did not correlate with NAFLD in this pediatric study.
Area Of Science
- Pediatric Endocrinology
- Hepatology
- Metabolic Disorders
Background
- Elevated serum uric acid (sUA) exhibits pro-inflammatory and pro-oxidative effects.
- Growing evidence suggests a link between sUA and pediatric Non-alcoholic fatty liver disease (NAFLD) in obese children.
Purpose Of The Study
- To evaluate the association between serum uric acid (sUA) levels, the sUA/creatinine (Cr) ratio, and pediatric NAFLD in obese children.
- To compare sUA and sUA/Cr levels between obese children with and without NAFLD, and healthy controls.
Main Methods
- A single-center, cross-sectional study involving 228 obese children (9-18 years) and 167 healthy controls.
- NAFLD diagnosis was based on ultrasound, excluding other hepatic diseases.
- Serum uric acid (sUA) and creatinine (Cr) levels were measured, and the sUA/Cr ratio was calculated.
Main Results
- Obese children showed significantly higher sUA and sUA/Cr levels compared to controls (p < 0.001).
- NAFLD was diagnosed in 74.2% of obese children.
- Elevated sUA/Cr ratio, waist circumference (WC), and ALT were associated with increased NAFLD risk (OR = 1.323 for sUA/Cr).
- No significant correlation was found between sUA levels alone and NAFLD.
Conclusions
- The sUA/Cr ratio, elevated waist circumference, and ALT are associated with an increased risk of NAFLD in obese children.
- The sUA/Cr ratio may serve as a potential biomarker for NAFLD in pediatric obesity.
- Serum uric acid levels alone are not correlated with NAFLD in this pediatric cohort.
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