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Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

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Related Experiment Video

Updated: Jun 7, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Optimizing DCD donor liver function with resveratrol during machine perfusion.

Chunbao Jiao1,2, Mingqian Li2, Xiaodong Sun2

  • 1Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH, 44195, USA.

Scientific Reports
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

Resveratrol enhances subnormothermic machine perfusion (SNMP) for liver grafts, improving viability and reducing injury markers. This mitochondrial-targeted approach shows promise for better organ preservation and long-term outcomes.

Keywords:
Liver transplantationMitochondriaResveratrolSubnormothermic machine perfusion

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Area of Science:

  • Organ transplantation
  • Machine perfusion
  • Mitochondrial repair

Background:

  • Ischemia-reperfusion injury significantly impacts liver graft viability.
  • Machine perfusion techniques are being explored to improve graft preservation.
  • Mitochondrial function is critical for graft survival post-transplantation.

Purpose of the Study:

  • To investigate the efficacy of resveratrol in enhancing subnormothermic machine perfusion (SNMP) for liver grafts.
  • To assess the impact of resveratrol on mitochondrial repair and graft quality.
  • To evaluate resveratrol's potential in mitigating ischemia-reperfusion injury during liver preservation.

Main Methods:

  • Rat donor livers underwent donation after circulatory death (DCD) warm ischemia.
  • Livers were preserved using static cold storage (SCS), SNMP, or SNMP with resveratrol (SNMP-RES).
  • Biochemical, transcriptomic, inflammatory, and histological analyses were performed post-perfusion.

Main Results:

  • Resveratrol significantly reduced perfusate AST and flavin mononucleotide (FMN) levels during SNMP.
  • SNMP with resveratrol decreased inflammatory cytokine levels and improved liver tissue morphology.
  • Transcriptomic analysis revealed upregulation of regenerative pathways (Notch, Wnt) and downregulation of innate immune response with resveratrol.

Conclusions:

  • Resveratrol enhances the protective effects of SNMP, improving liver graft quality and viability.
  • Flavin mononucleotide (FMN) shows potential as a marker for liver quality during SNMP.
  • Mitochondrial-targeted strategies, like resveratrol supplementation, hold promise for improving organ preservation and long-term transplant outcomes.