Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Life Histories01:29

Life Histories

22.4K
Overview
22.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolome remodeling with reverse-engineered exclusive enteral nutrition in children with active Crohn's disease.

Inflammatory bowel diseases·2026
Same author

An interpretable machine learning framework for dog breed inference and ancestry decomposition.

bioRxiv : the preprint server for biology·2026
Same author

ssNetShift: single-sample metabolic network rewiring reveals hidden prognostic subtypes beyond clinical staging in gastric cancer.

Briefings in bioinformatics·2026
Same author

Mapping the canine gut microbiome: insights from the Dog Aging Project.

Nature communications·2026
Same author

Blood biomarkers and breed genetics of aging in pet dogs.

bioRxiv : the preprint server for biology·2026
Same author

Correction: What's in a name? Metabolite identification: challenges and pitfalls in untargeted metabolomics.

Metabolomics : Official journal of the Metabolomic Society·2026

Related Experiment Video

Updated: Jan 10, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

35.4K

Early-Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies.

Benjamin R Harrison1, Yangxi Sun2, Tom Nonacs2

  • 1Department of Anesthesiology and Pain Medicine, Northwest Metabolomics Research Center, University of Washington, Seattle, Washington, USA.

Aging Cell
|November 27, 2025
PubMed
Summary

Even in genetically identical flies, climbing behavior variation predicts mortality. Metabolomics revealed differing metabolite abundances, identifying potential biomarkers for intrinsic mortality risk in aging research.

Keywords:
covariance networksisogenic variationmetabolomicsmortality

More Related Videos

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

19.7K
The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster
07:21

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster

Published on: June 8, 2018

12.1K

Related Experiment Videos

Last Updated: Jan 10, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

35.4K
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

19.7K
The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster
07:21

The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster

Published on: June 8, 2018

12.1K

Area of Science:

  • Gerontology and Drosophila melanogaster research.
  • Investigating biological mechanisms of aging and mortality variation.

Background:

  • Aging studies typically control environmental and genetic variables, yet lifespan variation persists even in isogenic populations.
  • Understanding the sources of this intrinsic mortality variation is crucial for aging research.

Purpose of the Study:

  • To explore how behavioral variation within isogenic Drosophila populations can predict mortality risk and stress sensitivity.
  • To identify metabolic biomarkers associated with intrinsic mortality risk.

Main Methods:

  • Utilizing climbing behavior in Drosophila melanogaster as a proxy for stratifying isogenic cohorts.
  • Employing metabolomics to analyze metabolite abundance differences among behavioral fractions.
  • Investigating metabolite covariance structures in genetically identical, but fractionated, fly populations.

Main Results:

  • Fractionation of isogenic flies based on climbing behavior significantly predicted future mortality risk and stress sensitivity.
  • Metabolomics identified specific metabolites with differing abundances between short-lived and long-lived fractions.
  • Analysis revealed metabolite covariance patterns linked to intrinsic mortality risk.

Conclusions:

  • Climbing behavior in Drosophila is a valuable indicator of intrinsic mortality risk and stress sensitivity.
  • Specific metabolites and metabolic pathways can serve as candidate biomarkers for predicting mortality risk in genetically uniform populations.
  • This study provides novel insights into the biological basis of lifespan variation.