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Updated: Jan 10, 2026

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
Published on: January 20, 2023
Molecular effects of transposable element sequences in mammalian cells
Ming-Ching C Wen1, Joshua D Welch2,3
1Gilbert S Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
None:
Transposable elements (TEs) are often epigenetically repressed in eukaryotic cells, but still affect the molecular state of the cell in certain contexts. A flurry of recent studies have elucidated new effects of TE sequences in eukaryotic cells. We review these emerging molecular effects of TEs, including a variety of new mechanisms by which TE sequences affect the cell, including pre- and post-transcriptional regulation of gene expression; cell-to-cell transmission of genes within a multicellular organism through virus-like activity; and RNA-guided DNA insertion. Recent demonstration of TE-guided genome editing underscores the importance of these investigations for both basic and translational research. Future work is needed to continue to unravel the molecular effects of TE sequences across developmental stages, across cell types, and in various diseases.
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