Impact of multimorbidity on health-related quality of life: the mediation role of intrinsic capacity - evidence from the WHO ICOPE pilot program in Lianyungang of China (2024)
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Summary
This summary is machine-generated.Multimorbidity significantly increases the risk of poor health-related quality of life (HRQoL) in older adults. Intrinsic capacity (IC) plays a key role, mediating this association and offering a target for interventions.
Area Of Science
- Gerontology
- Public Health
- Health Services Research
Background
- Health-related quality of life (HRQoL) is demonstrably linked to multimorbidity.
- The precise mechanisms underlying this association, particularly the role of intrinsic capacity (IC), require further elucidation.
Purpose Of The Study
- To investigate the relationship between multimorbidity and HRQoL in older adults.
- To explore the mediating effect of intrinsic capacity (IC) on the association between multimorbidity and HRQoL.
Main Methods
- A cross-sectional study involving 468 adults aged ≥60 years was conducted.
- Multimorbidity was assessed using clinical judgment, Charlson Comorbidity Index, and Cumulative Illness Rating Scale for Geriatrics.
- HRQoL was measured by EQ-5D-3L, and IC was evaluated per WHO ICOPE guidelines. Logistic regression and mediation models were employed.
Main Results
- Each additional comorbidity was associated with a 22% increased risk of reduced HRQoL.
- Individuals with 1, 2-3, or ≥4 conditions faced significantly higher risks of poor HRQoL (148%, 172%, 194% increase, respectively).
- Intrinsic capacity (IC) was found to mediate 25.90% of the association between multimorbidity and HRQoL.
Conclusions
- Multimorbidity is a significant risk factor for diminished HRQoL in older populations.
- Intrinsic capacity (IC) serves as a crucial indicator for identifying individuals at risk of poor HRQoL and mediates the impact of multimorbidity on quality of life.