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Local Protein Synthesis at Synapses: A Driver for Synapse Diversification.

Ezgi Daskin1, Stanley Van1, Anne-Sophie Hafner1

  • 1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.

Journal of Neurochemistry
|November 27, 2025
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Summary
This summary is machine-generated.

Local protein synthesis in neurons is key for adapting synaptic function. This review explores mRNA transport and local synthesis, crucial for memory consolidation and presynaptic diversification.

Keywords:
local translationmRNA targetingmemory engramssynaptic plasticity

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Synaptic Plasticity

Background:

  • Local protein synthesis in neuronal processes is vital for rapid proteome remodeling at synapses.
  • This capability allows neurons to dynamically adapt synaptic functions in response to neural activity.

Purpose of the Study:

  • To review mechanisms of targeted mRNA transport into dendrites and axons.
  • To present evidence for local mRNA recruitment during synaptic plasticity.
  • To highlight the role of local protein synthesis in memory engram formation and stabilization.

Main Methods:

  • Literature review of studies on mRNA transport and local protein synthesis in neurons.
  • Analysis of evidence linking local protein synthesis to synaptic plasticity and memory.

Main Results:

  • Diverse mechanisms facilitate targeted mRNA transport into neuronal processes.
  • Local mRNAs are actively synthesized during synaptic plasticity.
  • This process contributes to the establishment and stabilization of memory engrams.

Conclusions:

  • Presynaptic protein synthesis diversifies presynaptic terminals.
  • This diversification is essential for durable consolidation and specificity of memory engrams.