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Updated: Jan 10, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Minimally Invasive Peripheral Neuromodulation for Postamputation Stump Neuroma: A Case Report
David Bailey1, Cameron Brandon1, Lekhaj C Daggubati2
1Penn State College of Medicine, Hershey, PA.
Background:
Postamputation neuromas are a significant cause of pain and suffering in amputees. In patients who are nonresponsive to medical therapy, open surgery is often required but has limited efficacy.
Case Report:
Here we present a case of the successful use of percutaneous peripheral nerve stimulation in a 77-year-old man with a postamputation neuroma that was refractory to medical therapy. He had significant pain reduction allowing a return to his daily activities.
Conclusion:
This case report demonstrates that peripheral nerve stimulation may reduce pain in patients with postamputation neuroma. Percutaneous peripheral nerve stimulation is a promising treatment to reduce pain and improve patient function without irreversible manipulation.

