The Application of Gamma-Range Auditory Steady-State Responses in Animal Models: A Semi-Structured Literature Review
Urte Jasinskyte1, Cestmir Vejmola2,3, Robertas Guzulaitis1
1Institute of Bioscience, Life Sciences Center, Vilnius University, 10257 Vilnius, Lithuania.
Brain Sciences
|November 27, 2025
Summary
Gamma-range auditory steady-state responses (ASSRs) in animal models show promise as biomarkers for neural network function in psychiatric disorders. Harmonizing methods and including behavioral factors will enhance their clinical translation.
Area of Science:
- Neuroscience
- Psychiatry
- Biomarkers
Background:
- Gamma-range auditory steady-state responses (ASSRs) are emerging biomarkers for neural network function.
- While studied in humans, their use in animal models offers mechanistic insights into neuropsychiatric and neurodevelopmental disorders.
- Current animal research on ASSRs is fragmented due to methodological variability.
Purpose of the Study:
- To review and synthesize findings on gamma-range ASSRs in animal models relevant to psychiatric and developmental conditions.
- To assess the translational potential of gamma-range ASSRs as biomarkers.
Main Methods:
- A systematic literature search was conducted in March 2025 on PubMed and Scopus.
- Studies focused on gamma-range ASSRs (30-100 Hz) in animal models related to psychiatric and developmental disorders.
- Included manipulations such as pharmacological, genetic, lesion-based, and developmental interventions.
Main Results:
- Rodents were the primary animal models, with some non-human primate studies.
- Gamma-range ASSRs were sensitive to NMDA receptor antagonism and state/trait factors.
- ASSRs showed region- and layer-specific generation in the auditory cortex, with translational potential in alternative paradigms.
Conclusions:
- Animal research validates gamma-range ASSRs as cross-species indicators of circuit dysfunction in psychiatric and neurodevelopmental disorders.
- Methodological harmonization, inclusion of sex and behavioral state, and inter-laboratory replication are crucial for translational utility.
- Strengthening these aspects will improve ASSRs' value for early detection, patient stratification, and treatment monitoring.
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