Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.1K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.1K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

8.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.6K
Redox Reactions01:27

Redox Reactions

856
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
856
Redox Reactions01:24

Redox Reactions

58.1K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
58.1K
Structure and Function of Platelets01:18

Structure and Function of Platelets

2.8K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.8K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD137 in cancer therapy - bench to bedside.

Immunotherapy·2026
Same author

The need for dried plasma-Still a national issue: Where are we and recommendations.

Transfusion·2026
Same author

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same author

Next generation spray-dried on-demand plasma: A multicenter, randomized, dose-escalation, first-in-human safety study.

Transfusion·2026
Same author

Bone Marrow Stem Cell Connexins: Misconceptions and New Insights.

Blood·2026
Same author

Unveiling karyoskeletal dynamics in chromatin organization and gene regulation in haematopoietic cell physiology and pathology.

Open biology·2026

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
06:35

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

Published on: March 29, 2024

1.1K

Redox Control in Platelet Activity and Therapy.

Laura M Dionisio1, Yi Zheng2,3, Jose A Cancelas1,4,5

  • 1Division of Bone Marrow Transplantation and Cell Therapies, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Antioxidants (Basel, Switzerland)
|November 27, 2025
PubMed
Summary

Platelets generate reactive oxygen species (ROS) for signaling and blood clot formation. Maintaining redox balance is crucial for platelet function and preventing diseases linked to oxidative stress.

Keywords:
activityplateletredox regulationtherapy

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.5K
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.3K

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
06:35

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

Published on: March 29, 2024

1.1K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.5K
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.3K

Area of Science:

  • Hematology
  • Biochemistry
  • Cellular Physiology

Background:

  • Redox balance is critical for platelet function and cellular homeostasis.
  • Platelet activation generates reactive oxygen species (ROS) essential for collagen-dependent thrombus formation.
  • Imbalances in redox state contribute to various diseases, including thrombosis and cardiovascular disorders.

Purpose of the Study:

  • To explore the role of redox regulation in platelet physiology.
  • To investigate the enzymatic sources of ROS in platelets.
  • To understand the implications of oxidative stress in platelet storage and disease.

Main Methods:

  • Review of enzymatic systems involved in platelet ROS production (NOX, COX, XO, mitochondria).
  • Analysis of the impact of oxidative and reductive stress on platelet function.
  • Examination of redox pathways in transfusion medicine and platelet storage.

Main Results:

  • Nicotinamide adenine dinucleotide (phosphate) oxidases (NOX) are primary ROS sources in platelets.
  • Mitochondrial dysfunction drives oxidative stress during platelet storage, impairing hemostatic function.
  • Disrupted redox balance is implicated in bleeding disorders, thrombosis, and cancer.

Conclusions:

  • Targeting platelet redox pathways offers a potential therapeutic strategy.
  • Understanding platelet redox biology is key to improving platelet storage and treating related diseases.
  • Platelet redox regulation is vital for hemostasis and overall health.