Innovative Plant-Based Nutraceuticals: Enhancing Iron Bioavailability to Address Iron Deficiency Anaemia.

Area of Science:

• Nutritional Science
• Biochemistry
• Pharmacology

Background:

• Iron deficiency anaemia (IDA) impacts 25% of the global population, disproportionately affecting women and children.
• Conventional iron supplements provide temporary relief but cause adverse effects and exacerbate oxidative stress.
• There is a need for effective, well-tolerated iron sources to improve patient adherence and manage IDA.

Purpose of the Study:

• To develop a plant-based nutritional formula rich in bioavailable iron and antioxidants.
• To evaluate the efficacy and bioavailability of the plant-based nutraceuticals in an animal model of IDA.
• To assess the safety and impact on oxidative stress of the novel formulation.

Main Methods:

• Chemical analysis of edible plants to identify iron content and absorption inhibitors.
• Formulation of a plant-based nutritional product using selected ingredients.
• In vivo studies using rats with IDA to assess iron bioavailability and blood parameters after 28 days of oral administration.

Main Results:

• The plant-based nutraceuticals demonstrated significant improvements in IDA-associated blood parameters in rats.
• Oral administration of the formula for 28 days showed good iron bioavailability.
• The nutraceuticals did not impede the benefits of iron supplementation and were devoid of adverse effects.

Conclusions:

• Plant-based nutraceuticals can be an effective source of bioavailable iron for managing IDA.
• The developed formula offers a potential alternative to conventional iron supplements, improving adherence and reducing side effects.
• This approach aligns with global initiatives to enhance IDA management through innovative nutritional strategies.