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Related Experiment Videos

Plantar ulcers with osteomyelitis underneath. A bacteriological study.

D D Palande, C de Severy, M S Rajagopalan

    Leprosy in India
    |July 1, 1977
    PubMed
    Summary

    This study on plantar ulcers and osteomyelitis found mixed bacterial infections were common. Chloramphenicol showed the most effectiveness, while Penicillin and Streptomycin were less effective and should be used cautiously.

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    Area of Science:

    • Infectious Diseases
    • Bacteriology
    • Podiatric Medicine

    Background:

    • Plantar ulcers with underlying chronic osteomyelitis present a significant clinical challenge.
    • Understanding the microbial etiology and antibiotic susceptibility is crucial for effective treatment.

    Purpose of the Study:

    • To identify the common infecting organisms in plantar ulcers with chronic osteomyelitis.
    • To determine the in vitro sensitivity of these organisms to commonly available antibiotics.

    Main Methods:

    • Retrospective analysis of 39 consecutive cases of plantar ulcers with chronic osteomyelitis.
    • Microbiological culture and sensitivity testing for isolated organisms.

    Main Results:

    • Mixed bacterial infections were prevalent, with Staphylococcus, Streptococcus, and Proteus mirabilis being the most common.
    • Chloramphenicol demonstrated the broadest effectiveness against the isolated pathogens.
    • High resistance rates (70%) were observed for Staphylococcus strains against Penicillin.

    Conclusions:

    • Empirical antibiotic therapy, particularly with Penicillin and Streptomycin, should be reconsidered due to observed resistance patterns.
    • Targeted antibiotic selection based on culture and sensitivity testing is recommended for managing these complex infections.

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