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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
Published on: November 30, 2013
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Non-Coding RNAs as Emerging Regulators in Kidney Pathophysiology: From Molecular Mechanisms to Therapeutic Potential
Petar Todorović1, Nikola Pavlović2, Mirko Maglica3
1Department of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.
Genes
|November 27, 2025
Summary
Non-coding RNAs (ncRNAs) are key regulators of kidney function and disease. Their dysregulation drives kidney diseases, but they also offer potential as diagnostic biomarkers and therapeutic targets for precision nephrology.
Area of Science:
- Renal biology and pathophysiology
- Molecular mechanisms of gene regulation
- Biomarker discovery and therapeutic development
Background:
- Kidney function depends on complex gene regulatory networks.
- Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are crucial regulators.
- Dysregulation of ncRNAs is implicated in major kidney diseases like diabetic nephropathy and chronic kidney disease.
Purpose of the Study:
- To review the role of ncRNAs in renal biology and pathophysiology.
- To explore ncRNAs as diagnostic biomarkers and therapeutic targets in nephrology.
- To integrate mechanistic insights with translational applications of ncRNAs.
Main Methods:
- Review of molecular mechanisms of ncRNA function in the kidney.
- Analysis of ncRNA dysregulation in various kidney diseases.
- Evaluation of ncRNAs as biomarkers and therapeutic agents.
Main Results:
- ncRNAs modulate key renal processes including podocyte integrity, tubular adaptation, and immune response.
- Pathogenic ncRNAs promote kidney injury, while protective ncRNAs mitigate it.
- ncRNAs are stable and detectable in biofluids, serving as potential minimally invasive biomarkers.
Conclusions:
- ncRNAs play dual roles as mediators and targets in kidney diseases.
- ncRNA-based biomarkers offer diagnostic and prognostic value for early detection and risk stratification.
- ncRNA-based therapeutics hold promise for precision nephrology and novel interventions.
Keywords:
biomarkerscircular RNAsfibrosiskidney diseaselong non-coding RNAsmicroRNAsnon-coding RNAstherapeutic targetingMore Related Videos
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