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Confocal Fluorescence Microscopy

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

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Related Experiment Video

Updated: Jan 10, 2026

Laser Nanosurgery of Cerebellar Axons In Vivo

Laser Nanosurgery of Cerebellar Axons In Vivo

Published on: July 28, 2014

Laser Confocal Microscopy May Be a Useful Tool in Neuropathological Intraoperative Examination.

Deborah Dardano^1,2, Anna Bilotta², Gianmarco Gallucci²

¹Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.

Diagnostics (Basel, Switzerland)

|November 27, 2025

Summary

This summary is machine-generated.

The Histolog® Scanner offers rapid, high-resolution imaging for intraoperative brain tumor diagnosis, improving margin visualization and preserving tissue for further analysis, potentially setting a new standard in neurosurgery.

Area of Science:

Neurosurgery
Pathology
Medical Imaging

Background:

Keywords:

Histolog® Scanner brain tumors surgery intraoperative pathological examination laser confocal microscopy margins

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In Vivo Fiber-Coupled Pre-Clinical Confocal Laser-scanning Endomicroscopy pCLE of Hippocampal Capillaries in Awake Mice

In Vivo Fiber-Coupled Pre-Clinical Confocal Laser-scanning Endomicroscopy pCLE of Hippocampal Capillaries in Awake Mice

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Last Updated: Jan 10, 2026

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In Vivo Fiber-Coupled Pre-Clinical Confocal Laser-scanning Endomicroscopy pCLE of Hippocampal Capillaries in Awake Mice

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Traditional intraoperative neuropathological diagnosis methods like frozen sections can cause artifacts and consume valuable tissue.

The Histolog® Scanner, a confocal microscopy device, provides a potential alternative for rapid, in-situ tissue analysis.

Current methods may limit the ability to precisely define tumor margins during surgery.