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Updated: Jan 10, 2026
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Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
Published on: August 20, 2021
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The Microbiome and Genitourinary Cancers: A New Frontier
Timothy B Winslow1, Sophia Gupta1, Vedha Sai Vaddaraju1
1Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USA.
Cancers
|November 27, 2025
Summary
The gut microbiome influences cancer treatment. Modifying the microbiome may improve immunotherapy effectiveness for urothelial and renal cell carcinoma patients resistant to current therapies.
Area of Science:
- Oncology
- Immunology
- Microbiology
Background:
- Immune checkpoint inhibitors and targeted agents have improved outcomes in urothelial and renal cell carcinoma.
- A significant subset of patients exhibit resistance to these treatments, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the role of the microbiome in cancer immunity.
- To explore the microbiome's potential to enhance immunotherapy response.
- To discuss implications for urothelial and renal cell carcinoma treatment.
Main Methods:
- Literature review of recent advances in microbiome research.
- Analysis of the microbiome's interaction with immunotherapy.
- Exploration of microbiome modification strategies.
Main Results:
- The microbiome dynamically regulates the immune system.
- Microbiome composition impacts immunotherapy efficacy.
- Emerging strategies focus on microbiome modulation for enhanced treatment response.
Conclusions:
- The microbiome represents a promising target for overcoming treatment resistance in urothelial and renal cell carcinoma.
- Future research should focus on microbiome-based interventions to improve patient outcomes.
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