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High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network

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Published on: January 29, 2018

Novel CTC Detection Method in Patients with Pancreatic Cancer Using High-Resolution Image Scanning.

Takahiro Manabe¹, Tomoyuki Okumura¹, Kenji Terabayashi²

¹Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 9300194, Japan.

|November 27, 2025

Summary

A new method for detecting circulating tumor cells (CTCs) in pancreatic cancer shows promise. This approach quantifies cell luminance for more objective CTC identification in pancreatic ductal adenocarcinoma (PDAC) patients.

Keywords:

circulating tumor cells high-resolution image scanning liquid biopsy negative enrichment pancreatic ductal adenocarcinoma

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Area of Science:

Oncology
Biomarker Discovery
Medical Diagnostics

Background:

Early diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC) require reliable biomarkers.
Circulating tumor cells (CTCs) show potential as cancer biomarkers, but their detection in PDAC is challenging.
High-performance CTC detection methods are crucial for understanding their role in PDAC.

Purpose of the Study:

To evaluate a novel method for detecting circulating tumor cells (CTCs) in patients with pancreatic ductal adenocarcinoma (PDAC).
To assess the utility of quantifying cell luminance for objective CTC identification.

Main Methods:

Peripheral blood samples from 38 PDAC patients and 17 healthy controls were analyzed.
Cells were enriched and stained for EpCAM and cell surface vimentin (CSV).
High-resolution fluorescence microscopy and automated image analysis quantified cell luminance.

Main Results:

The EpCAM assay achieved a sensitivity of 0.74, specificity of 0.76, and AUC of 0.84 in distinguishing PDAC patients from controls.
A CTC-positivity rate of 76.3% was observed in PDAC patients at the optimal threshold.
The CSV assay did not yield a valid threshold for distinguishing between groups.

Conclusions:

High-resolution image scanning with cell luminance quantification offers an objective method for CTC identification.
This technique holds potential for improving CTC detection in pancreatic cancer.