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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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The Involvement of the Peptidergic Systems in Breast Cancer Development.
Manuel L Sánchez1, Prema Robinson2, Zal Italia2
1Laboratory of Neuroanatomy of the Peptidergic Systems, Institute of Neurosciences of Castilla and León (INCYL), University of Salamanca, 37007 Salamanca, Spain.
Cancers
|November 27, 2025
Summary
Peptidergic systems offer significant potential for breast cancer treatment by targeting peptide receptors. Research highlights their roles in diagnosis, prognosis, and developing novel antitumor agents.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Peptidergic systems are extensively involved in breast cancer progression.
- These systems are crucial for understanding molecular mechanisms and developing drug strategies.
Purpose of the Study:
- To review the role of peptidergic systems in breast cancer.
- To explore the potential of peptide receptor agonists and antagonists in breast cancer treatment.
Main Methods:
- Literature review of studies on peptidergic systems in breast cancer.
- Analysis of peptide interactions with breast cancer cells and their effects.
Main Results:
- Breast cancer cells overexpress peptide receptors, interacting with oncogenic, anticancer, or dual-acting peptides.
- Peptides and their receptor modulators show potential as antitumor agents by inhibiting proliferation, migration, invasion, and angiogenesis, and inducing apoptosis.
- Various strategies, including receptor silencing and targeted antibodies, are being developed.
Conclusions:
- Peptidergic systems hold immense clinical potential for breast cancer treatment.
- Further translational research is needed to exploit these systems for improved diagnosis and therapy.
- Specific peptide receptor antagonists and agonists show promise for future breast cancer interventions.
Keywords:
anticancer peptidesbradykinincorticotropin-releasing factorglucagon-like peptide 1kisspeptinneuromedinneuropeptide Yoncogenic peptidespeptide receptor antagonistssubstance PMore Related Videos
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