Transforming Liver Cancer Therapy: Integrating Molecular Profiling with Precision and Transplant-Based Care

Area of Science:

• Hepatology
• Oncology
• Immunology

Background:

• Hepatocellular carcinoma (HCC) is a major global cause of cancer mortality.
• Current systemic therapies offer limited survival benefits for many HCC patients.
• Understanding HCC's molecular and immune landscape is crucial for therapeutic advancement.

Purpose of the Study:

• To review recent progress in HCC molecular classification and immune modulation.
• To examine how translational insights are redefining clinical practice for HCC.
• To highlight the integration of molecular markers in liver transplantation and HCC management.

Main Methods:

• Review of recent scientific literature on HCC.
• Analysis of molecular and immunological profiling studies.
• Examination of innovations in liver transplantation and liquid biopsy.

Main Results:

• Emergence of novel therapeutic paradigms including targeted agents and immune checkpoint blockade.
• Advancements in multi-omics profiling and liquid biopsy are reshaping HCC treatment algorithms.
• Integration of molecular markers is influencing transplant eligibility and post-transplant care.

Conclusions:

• Translational insights from molecular and immune studies are redefining HCC clinical practice.
• Precision-oriented frameworks integrating molecular data are essential for patient-centered HCC care.
• Innovations in diagnostics and transplantation offer new hope for improving HCC outcomes.