Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
The Extracellular Matrix01:29

The Extracellular Matrix

11.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
11.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helicobacter 30 Years On: A Message From the Editor, Emeritus.

Helicobacter·2026
Same author

<i>Helicobacter pylori</i> and Cancer: What's the Link?

Clinical and experimental gastroenterology·2026
Same author

Ecological and edaphic evaluation of Erysimum croceum populations in the Zailiyskiy Alatau: implications for conservation.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Vonoprazan High-Dose Dual, Vonoprazan Triple, and Rabeprazole Reverse Hybrid Therapies for First-Line Treatment of Helicobacter pylori Infection: A Multicenter Randomized Trial.

The American journal of gastroenterology·2025
Same author

Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans-A Preliminary Investigation.

Nutrients·2025
Same author

Crises in Antimicrobial Stewardship: Misuse of Clarithromycin for <i>Helicobacter pylori</i> Therapy.

Pharmacoepidemiology·2025
Same journal

RETRACTED: Sabir et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. <i>Cancers</i> 2021, <i>13</i>, 3396.

Cancers·2026
Same journal

Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

Cancers·2026
Same journal

Correction: Peñalver et al. Guidelines for Diagnosis, Treatment, and Follow-Up of Patients with Follicular Lymphoma-Spanish Lymphoma Group (GELTAMO) 2026. <i>Cancers</i> 2026, <i>18</i>, 395.

Cancers·2026
Same journal

Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

Cancers·2026
Same journal

Age-Stratified Long-Term Outcomes of Immune Checkpoint Inhibitors for Stage IV Melanoma and NSCLC in The Netherlands: A Population-Based Study.

Cancers·2026
Same journal

Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.

Cancers·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract ECME-based Three-dimensional System
10:55

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract ECME-based Three-dimensional System

Published on: January 8, 2018

11.5K

Elastic Cytomatrix Dynamics Influences Metabolic Rate and Tumor Microenvironment Formation.

Tattym E Shaiken1,2,3,4, Tulendy T Nurkenov3, Meruyert S Kurmanbayeva3

  • 1Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Cancers
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Cancer cells reprogram energy metabolism to fuel their complex internal structure (cytomatrix). This altered cytomatrix, integrated with the extracellular matrix, drives tumor microenvironment formation and cancer cell dedifferentiation.

Keywords:
Warburg effectactincytomatrixextracellular matrixmalignant transformationmetabolismtumor microenvironment

More Related Videos

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.8K
High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-&#946; on the Epithelial-to-Mesenchymal Transition
13:34

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition

Published on: June 1, 2019

9.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract ECME-based Three-dimensional System
10:55

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract ECME-based Three-dimensional System

Published on: January 8, 2018

11.5K
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.8K
High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-&#946; on the Epithelial-to-Mesenchymal Transition
13:34

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition

Published on: June 1, 2019

9.9K

Area of Science:

  • Cell Biology
  • Biophysics
  • Cancer Research

Background:

  • Healthy cells use mitochondrial respiration for cytomatrix mechanics.
  • Cancer cells exhibit the Warburg effect (glycolytic fermentation) to power their cytomatrix.
  • The cytomatrix is an integrated structure where function and form are inseparable.

Purpose of the Study:

  • To describe the physical and chemical processes of the integrated cytomatrix cytoarchitecture.
  • To propose mechanisms for tumor microenvironment formation.
  • To discuss the role of AI in modeling cytomatrix and tumor microenvironment development.

Main Methods:

  • Analysis of cytomatrix mechanics in healthy and cancer cells.
  • Investigation of extracellular and intracellular matrix interactions.
  • Exploration of protein translocation and cell surface modifications.

Main Results:

  • The extracellular and intracellular cytomatrix function as integrated elastic solid phases.
  • Tumor microenvironment formation is linked to mutational burden, protein alterations, and immune cell attraction.
  • Tumor insulation disrupts cell recognition and signaling, affecting actin dynamics and leading to cancer cell dedifferentiation.

Conclusions:

  • The integrated cytomatrix and its interaction with the extracellular matrix are crucial in cancer progression.
  • Tumor microenvironment formation is a complex process influenced by cellular mechanics and mutations.
  • AI and neural network modeling offer promising avenues for understanding cytomatrix roles in cancer.