Radiomics in Action: Multimodal Synergies for Imaging Biomarkers.

Area of Science:

• Radiology and Medical Imaging
• Quantitative Imaging Analysis
• Biomarker Development

Background:

• Radiomics shifts medical imaging from qualitative to quantitative analysis.
• It extracts high-throughput features from various imaging modalities like CT, MRI, and PET/CT.
• This enables characterization of tissue heterogeneity and development of imaging biomarkers.

Purpose of the Study:

• To review the historical evolution and methodological foundations of radiomics.
• To highlight clinical applications across oncology, cardiology, neurology, and musculoskeletal imaging.
• To discuss challenges and professional initiatives for standardization and clinical translation.

Main Methods:

• Narrative review of radiomics literature.
• Exploration of methodologies including acquisition, segmentation, feature extraction, and modeling.
• Discussion of supporting platforms and clinical applications.

Main Results:

• Radiomics enables the development of diagnostic, prognostic, and predictive imaging biomarkers.
• Clinical applications are demonstrated in major medical fields.
• Challenges include standardization, reproducibility, and interpretability, with initiatives like IBSI addressing these.

Conclusions:

• Radiomics holds significant promise for enhancing objectivity and reproducibility in radiology.
• Overcoming current challenges is key for clinical translation and integration into radiology reports.
• The vision is radiomics-augmented reports advancing precision medicine through validated biomarkers.