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Prognostic Evaluation of Lower Third Molar Eruption Status from Panoramic Radiographs Using Artificial
Ipek N Guldiken1, Alperen Tekin2, Tunahan Kanbak3
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istinye University, Ayazağa Mahallesi, Azerbaycan Caddesi, Vadistanbul 4A Blok, 34396 Sariyer, Istanbul, Turkey.
Bioengineering (Basel, Switzerland)
|November 27, 2025
Summary
Artificial intelligence (AI) models can predict third molar eruption status from panoramic radiographs. The ResNet50 deep learning model shows promise in aiding clinical decisions for impacted teeth.
Area of Science:
- Dentistry
- Artificial Intelligence
- Medical Imaging
Background:
- Prophylactic third molar extraction decisions are challenging due to conflicting guidelines and reliance on surgeon experience.
- Predicting the eruption status of impacted third molars is crucial for effective clinical management.
Purpose of the Study:
- To evaluate deep learning-based artificial intelligence (AI) for predicting the eruption status of impacted third molars.
- To develop a predictive model for final tooth positions to assist early clinical decision-making.
Main Methods:
- A retrospective study utilized 1102 panoramic radiographs annotated for eruption status (initial vs. definitive).
- Two deep learning architectures (InceptionV3, ResNet50) were trained and evaluated using hyperparameter tuning, model evaluation, and preprocessing assessment.
- Performance metrics included accuracy, recall, precision, and F1 score. Classical machine learning algorithms were also applied.
Main Results:
- The ResNet50 model with preprocessing achieved the highest performance (F1 score: 0.829).
- Model performance was better for definitive eruption cases (F1 score: 0.829) than initial cases (F1 score: 0.705).
- Clinical prediction accuracy was 83% for full eruption and 75% for impaction, with lower accuracy for partial impactions.
Conclusions:
- AI, particularly deep learning models like ResNet50, shows potential in supporting early prediction of third molar eruption status.
- These AI tools can enhance clinical decision-making regarding impacted third molars.
- Further development with larger datasets and optimization may lead to greater accuracy for routine clinical applications.

