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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
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Smart Biomaterials in Wound Healing: Advances, Challenges, and Future Directions in Intelligent Dressing Design
Yanlin Liu1, Liqin Ge1,2
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Bioengineering (Basel, Switzerland)
|November 27, 2025
Summary
Intelligent wound dressings actively monitor and respond to chronic wounds, offering a personalized therapy approach. These advanced systems aim to improve healing outcomes and reduce complications for patients with conditions like diabetic foot ulcers.
Area of Science:
- Biomedical Engineering
- Materials Science
- Regenerative Medicine
Background:
- Chronic wounds, including diabetic foot ulcers and pressure ulcers, present significant clinical challenges and a substantial economic burden.
- Persistent inflammation, infection risk, and poor tissue regeneration hinder healing in chronic wounds.
- Current wound care relies on passive dressings, highlighting the need for advanced therapeutic solutions.
Purpose of the Study:
- To review the landscape of intelligent wound dressings, focusing on their bioengineered designs and responsive functionalities.
- To discuss the potential of these advanced dressings in managing chronic wounds and improving patient outcomes.
- To identify key challenges and future directions for the clinical translation of smart wound technologies.
Main Methods:
- Comprehensive review of recent literature on intelligent wound dressing technologies.
- Categorization of dressings based on sensing and response mechanisms (pH, temperature, moisture, pressure, electrical, biosensing, shape-memory, drug release).
- Analysis of challenges related to clinical implementation, including biocompatibility, stability, scalability, cost, and regulatory approval.
Main Results:
- Intelligent wound dressings offer dynamic monitoring and response capabilities for the wound microenvironment.
- Various responsive systems are being developed, including pH-sensitive, temperature-responsive, moisture-responsive, pressure-sensing, electroactive, biosensor-integrated, shape-memory, and controlled drug-releasing dressings.
- Significant hurdles remain for clinical translation, encompassing biocompatibility, long-term stability, manufacturing, cost, patient adherence, and regulatory processes.
Conclusions:
- Intelligent wound dressings represent a paradigm shift in chronic wound management, moving towards personalized and continuous therapy.
- These advanced systems hold the potential to significantly enhance healing, reduce complications, and improve the quality of life for patients.
- Overcoming translational challenges is crucial for realizing the full clinical potential of smart wound dressing technologies.
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